The investigation of serum nuclear factor erythroid 2-associated factor 2 (NRF2) level in patients with aortic valve sclerosis

Cardiovascular diseases are one of the highest mortality diseases worldwide. Intracellular oxidative damage is known to be associated with cardiovascular diseases. In this study, nuclear factor erythroid 2 related factor 2, glycogen synthase kinase 3 beta (GSK-3ß), superoxide dismutase (SOD), catalase (CAT) activities, 4 -Hydroxynonenal (4-HNE) and Malondialdehyde (MDA), lipid peroxidation toxic products, levels were determined in the serum of the patient and control groups. A significant difference was found between the patient and control groups with ACS in the measured parameters. At the same time, there was a significant positive correlation between GSK3ß and Nrf2. As a result, it is thought that it will be beneficial to add Nrf2 activator and / or antioxidant substances in addition to the treatment applied to patients with ACS.