Comparison of preoperative and postoperative pentraxin-3 (PTX3) levels in patients undergoing elective coronary bypass surgery

Coronary artery disease (CAD) is an important health problem that develops due to atherosclerosis and is one of the main causes of mortality and morbidity in the world. The basis of atherosclerosis is an inflammatory process. Coronary artery bypass graft surgery (CABG) is an important and effective revascularization method in the treatment of CAD. The SYNTAX scoring system is used for angiographic determination of CAD severity and treatment planning. Pentraxin-3 (PTX3) is an inflammatory biomarker in the family of pentraxins, synthesized in cardiac circulation. In our study, we aimed to compare preoperative and postoperative PTX3 levels in patients undergoing elective CABG and to investigate the correlation between SYNTAX score and PTX3 levels. 38 patients were included in the study. PTX3 levels were measured preoperatively, postoperatively 7th and 24th hours. Cardiac enzymes and inflammatory biomarkers were measured simultaneously. Mean PTX3 levels were measured as 1.22±0.92 ng/ml preoperatively, 71.15±45.93 ng/ml at postoperative 7th hour and 31.38±31.48 ng/ml at postoperative 24th hour. A positive correlation was observed between PTX3 at 7th and 24th hours postoperatively and SYNTAX scores (p=0.001 and p=0.018). Patients were divided into 3 groups according to their SYNTAX scores. Postoperative PTX3 levels were highest in the high SYNTAX score group. This was followed by the medium and low SYNTAX score groups, respectively. Preoperative PTX3 levels were similar in different SYNTAX score groups (p=0.104); there was a significant difference between groups in PTX3 levels at the 7th and 24th hours postoperatively (p=0.024 and p=0.021). There was also a significant positive correlation between hsCRP and PTX3 preoperatively and at postoperative 7th hour (p=0.001 and p=0.002). In conclusion, since PTX3 levels increase with the severity of CAD, it can be useful in postoperative treatment planning.