A retrospective evaluation of the relationship between clinicopathological properties in glioblastomas, ki-67 prolification index, İDF-1, EGFR, p53 mutations with prognosis

Glioblastoma is the most common malignant brain tumor. In the literature, there are few reports examining the relationship between morphologic findings of glioblastomas and patient prognosis. The aim of this study was to investigate the effect of morphologic features (broad necrosis, focal necrosis, palisadized necrosis, microvascular proliferation, atypia, cellularity, lymphocyte infiltration, mitosis, cell type) observed in glioblastomas and IDH1, EGFR, p53 immunexpression results and ki-67 proliferation index on patient prognosis. In our study, we retrospectively evaluated the preparations of 166 patients diagnosed with glioblastoma between 2014 and 2017 at the Department of Pathology, Faculty of Medicine, Uludag University. Morphological findings (broad necrosis, focal necrosis, palisadized necrosis, microvascular proliferation, atypia, cellularity, lymphocyte infiltration, mitosis, cell type) were classified according to their presence/absence or intensity. IDH1, EGFR, p53 expressions and ki-67 proliferation indices were grouped according to staining/non-staining conditions or staining percentages. The relationship between these findings and postoperative survival time was investigated. As a result; there was no statistically significant relationship between morphologic findings, IDH1, EGFR, p53 expressions, ki-67 index and survival.