Evaluating of ARHGAP42 rs633185 gene polymorphism on blood pressure and arterial stiffness in hypertension cases

Objective: Hypertension (high blood pressure) is defined as a disease that contributes to the development of complications such as heart attack, stroke, heart failure, kidney failure, and shortens the life expectancy of both men and women.. Studies have started to identify common genetic variants that contribute to blood pressure changes. Some of these variants are the single nucleotide changes in the first intron of the ARHGAP42 gene (rs604723, rs633185, rs607562 and rs667575). The aim of this study was to find out whether ARHGAP42 rs: 633185 gene polymorphism is related to blood pressure, ambulatory blood pressure and arterial stiffness and to search for personalized treatment options for early diagnosis of hypertension disease. Results could help to more complex researches that contribute to the genetic profile of Turkish society. Materials and Methods: We studied with 79 hypertensive cases and 76 control groups. Recorded the datas of cases arterial stiffness and 24-hour ambulatory blood pressure measurements. We drew the blood samples from cases and completed the DNA isolation procedures. Results: We examined the genotype distributions of the patients with hypertension and the control group. CG genotype increased 1.89 times and GG genotype increased 4.55 times compared to the control group in hypertensive cases. When we examined the allele distributions, we found that the G allele increased 1,466 times in the hypertensive case group compared to the control group.