Molecular subtypes of i̇nvasive breast cancer: correlation between PET/CT and mri findings

PURPOSE: In our study, we investigated the diagnostic value of F18-FDG PET/CT and MRI findings in determining molecular subtypes of invasive breast cancer. In addition, the relationships between the volume measurements in PET/CT and MRI and the pathological volume of the mass were evaluated. METHODS and MATERİALS: A total of 55 primary invasive breast cancer masses in 51 female patients who had histopathological diagnosis and underwent FDG PET/CT and MRI before therapy were retrospectively analysed. The correlations between molecular subtypes and SUVmax, SUVmean, MImean, MTV and HU values from FDG PET/CT findings; shape, margin, intratumoral enhancement, kinetic curve type and ADC values (based on 2013 BI-RADS MRI classification) from MRI findings were evaluated. In addition, the relationships between the pathologic tumor volume and the tumor volume measured by MRI and PET/CT were evaluated. RESULTS: The SUVmax and SUVmean values of the luminal B subtype of invasive breast cancer were higher than the luminal subtype A (p = 0.002, p = 0.017, respectively); the triple negative subtype had a higher SUVmax value than the luminal subtype A (p = 0.028). There were statistically significant strong positive correlations between MTV and FTV (p= 0,000; r= 0,857); MTV and the pathologic tumor volume (p= 0,006, r= 0,796); FTV and the pathologic tumor volume (p= 0,006, r= 0,921).