For postoperative analgesia at orthopedic lower extremity surgery to determine optimal dosage of dexketoprofen trometamol

We aimed to determine optimum dosage of intravenous administrated dexketoprofen trometamol HCl at postoperative period for postoperative analgesia in orthopedic lower extremity surgery at ASA I-II patientsWe divided the patients in to 4 groups randomly and dosage regimens were determined like following doses: Group I 1 mg/kg tramadol HCl loading dose, 25 mg tramadol HCl bolus dose with patient controlled analgesia (PCA), group II received 50 mg dexketoprofen trometamol I.V. (25 mg 2x1) 25 mg bolus tramadol HCl with PCA, Group III received 75 mg deksketoprofen trometamol I.V. (25 mg 3x1), 25 mg bolus tramadol HCl with PCA, Group IV received 100 mg deksketoprofen trometamol I.V. (50 mg 2x1), 25 mg bolus tramadol HCl with PCA. The patients who vomitting neousea scale was more than 2 or the patients could not tolerate nausea and demand antiemetic drugs was administereted 10 mg I.V metoklopramid. 40 mg famotidin administrated for dyspepsia or other gastrointestinal side effects. First doses of drugs administrated before 30 minutes the end of the operation. Lock in period of the PCA device was programmed as 30 minutes and the maximum doses as 100 mg for four hours.We compared the groups for hemodynamic and respiratory parameters, postoperative pain score, sedation score nausea-vomitting and consumed tramadol HCl doses at 1., 6., 12. and 24. hours in the recovery room.In conclusion, for postoperative pain management, PCA with 100 mg deksketoprofen trometamol HCl is suitable dosage regimen to obtain desired level of analgesia, minimum advers effect and desired patient satisfaction.Key words: postoperative pain, patient controlled analgesia, tramadol HCl, dexketoprofen trometamol