Comparison of the operative, oncological and functional parameters of patients under 55 and over 65 years of age with high risk prostate cancer who underwent robot-assisted laparoscopic radical prostatectomy.

Prostate cancer, usually a disease of the elderly population, is very rare in men younger than 50 years old. Identifying patients with early-onset (<55) prostate cancer, predicting the prognosis of the disease, and planning the most appropriate treatment based on the patient's risk status is one of the main areas of study in urology. In our study, the operative, postoperative, oncological, and functional results of the robot-assisted laparoscopic radical prostatectomy (RYLRP) operation applied to patients diagnosed with high risk prostate cancer (RYLRP) in our clinic between February 2009 and December 2017 were compared. Patients with a history of neadjuvan treatment, very advanced comorbidity, preoperative metastasis, pelvic radiotherapy and secondary cancer history were excluded from these patients. The records of 312 patients were analyzed retrospectively. The patients were divided into two groups, under the age of 55 and over the age of 65 (Group-1: patients under the age of 55 -87; Group-2: above the age of 65-225 patients). Preoperative comorbid disease history was found to be high in Group 2 compared to Group 1 (p = 0.012). Intraoperative estimated bleeding amount was significantly higher in Group 1 compared to Group 2 (p = 0.036). In Group 2, patients had higher prostate prostate (p = 0.001), extra-capsular extension (p = 0.017), less nerve-sparing surgery (p = 0.008), and more pathological stage (p = 0.044). . Postoperative catheterization time (p = 0.001) was found to be higher in Group 2. In group 1 biochemical recurrence rates were lower (p = 0.001), early continence rates (p = 0.012 at the time the probe was pulled; 1st month p = 0.023; and 3rd month p = 0.04) were observed to be significantly higher (p <0.001). There was no statistically significant difference between the 6th month (p = 0.230) and the 12th month (p = 0.374) continence rates. In the postoperative period, potency was better observed in Group 1 (p = 0.001). Our findings and results showed that RYLRP is ultimately multimodal treatment in high-risk patients, especially in young patients, even in the non-comorbid part of patients over 65 years of age. only by surgery, a significant progression-free survival is achieved. But all YRPK patients after RYLRP; Patients should be informed that multimodal therapy, including radiotherapy and hormonal therapy, may be required due to PSA relapses during follow-up. Both patient groups in our study It should be kept in mind that the functional continence results of our patients are satisfactory. In addition, postoperative erectile function and continence are much better, especially in the young age group.