Relationship of serum irisin levels with coronary collateral devolepment

The most important determinants of coronary collateral circulation (CCC) developmentare total coronary arteryocclusion (CTO) or severe stenosis, diabetes mellitus, inflammation agent sandcell level as well as growth factor. On the pathophysiological processes of atherosclerosis of the effect of irisin were studied the last studies. Weinvestigated whether there is a possible connection between irisin and CCC. In our study, coronaryartery disease was diagnosed and included consecutively in patients with at least one stenosis of 90% or more. 41 cases with good CCC and 45 cases with poor CCC were included.When the characteristics of good and poor CCC group were compared; age, sexratio, body massindex (BMI),diabetes, hyperlipidemia, hypertension, smoking and family historyrates, fasting glucose, total cholesterol, triglycerid, high and low density lipoprotein cholesterol, creatinine and serum CRP levels were similar (All p values> 0.05). Serum iris levels did not differ between good CCC and poor CCC groups. (17585 [882-37741] pg / ml and (17504 [813-47683] pg / ml, p = 0.772) The percent ages of SVEF were similar between the two groups (p> 0.05). Therates of 3 vessels (p = 0.045) and CTO (p <0.01) were higher in the good collateral group. Serum iris levels were negatively correlated with fasting blood glucose (r = -0.199; p = 0.066) and triglyceride levels (r = -0.282; p = 0.009). Serum irisin has no correlation with age, BMI, TC, triglyceride, DYL-cholesterol, YY1-Cholesterol, creatinine, CRP and SVEF (p> 0.05 forall). Serum irisin levels were lower in patients with diabetes (= 41) (14485 [813-29398] pg / ml) than those with out diabetes (n = 45; 19724 [865-47683] pg / ml (p = 0.002). Those with CTO (n = 54; 18756 [813-47683] pg / ml) had higher irisin level than those without CTO (n = 32; 15906 [865-37741] pg / ml) (p = 0.038). In the stepwise linear regression analysis in our study, the main factor affecting serum irisin levels was found to be the presence of diabetes (R2 = 35.6, p = 0.001) and CTO (R2 = 20.1, p = 0.042). As a result, serum irisin levels are one of the biochemical markers that related to the development of CTO and its level are decreased in diabetics. Serum irisin levels have no role in the pathophysiology of collateral development. Key Words: Atherosclerosis, Coronarycollateral devolepment, İrisi