The diagnostic value of supar in newborns with neonatal sepsis diagnosis

The neonatal period is the first 28 days of life. Neonatal sepsisis the clinical form of the response of the newborn by mechanisms including inflammatory processes against the invasion of any tissue of the newborn by an infectious microorganism. Because of the serious mortality of neonatal sepsis, the rapid deterioration of the clinic and the unnecessary use of antibiotics, speed and specificity are very impoortant in the diagnostic process. The gold standard diagnostic method for neonatal sepsis is blood culture. In this study, the value of SUPAR values as a biomarker in the diagnosis of neonatal sepsis was investigated. The sample of the study consisted of 34 newborns diagnosed with clinical or proven neoantal sepsis and 20 control newborns. Relevant parameters were evaluated with venous blood samples. For rhe SUPAR cut-off value of >1160.8 ng/L for the diagnosis of neonatal sepsis, the sensitivity is 88.24%, the specificity is 100.00%. The mean SUPAR value in the neonatal sepsis group was higher than the control group. The first CRP measurements of the cases with SUPAR measurement >1160.8 ng/L were fount to be significantly higher. The first SUPAR measurement of cases with exitus was statistically significantly higher than those who were discharged. In the light of all these data, the SUPAR molecule is a candidate to be used as a new biomarker in the diagnosis of neonatal sepsis. However, multicenter studies involving more patients are needed on this subject. Keywords: neonatal sepsis, prematurity, SUPAR, diagnostic marker