Changes in the complete blood count and biochemical parameters during remission-induction-consolidation of bfm chemotherapy in childhood acute leukemia, mehmet ari, MD., dissertation,

.Aim. In this study, it was aimed to investigate the clinical features of childhood acute leukemia patients and the change in serum electrolyte levels during BFM chemotherapy remission-induction-consolidation process. Method. The study was carried out at the Van Dursun Odabaşı Medical Center Hospital Pediatric Hematology Outpatient Clinic between 1 January 2014 and 31 December 2018 by retrospectively examining the files of patients diagnosed with acute leukemia from the hospital records. For statistical significance, p <0.05 is accepted. Results. When immune phenotype is evaluated, 81.2% (n = 69) of the patients are ALL, 18.8% (n = 16) of them are AML. 56.5% of ALL patients are male, 43.5% are female and the average age is 7.4 ± 5.2. 68.8% (n = 11) of AML patients are boys, 31.3% (n = 5) are girls and the average age is 8.2 ± 5.5. In 14.5% (n = 10) of ALL patients relapse developed, 11.6% (n = 11.6) were ex. In AML patients, 6.3% (n = 1) relapse developed and 12.5% (n = 2) became ex. Hypokalaemia in 94.2% (n = 65), hyponatremia in 100.0% (n = 69), hypocalcaemia in 95.7% (n = 66), hypomagnesemia in 60.9% (n = 42), hypophosphatemia in 97.1% (n = 67) was observed of patients with ALL, Hypokalaemia in 75.0% (n = 12, hyponatremia in 81.3% (n = 13), hypocalcaemia in 81.3% (n = 13), hypomagnesemia in 43.8% (n = 7), hypophosphatemia in 87.5% (n = 14) was observed of AML patients Compared to patients who did not develop ex-relapses, in patients with ex-relapse hypophosphatemia in P1A, hypokatemia in 1.HR1 and 2.HR3, hyponatremia in 2.HR2, and hypomagnesaemia in 2.HR3 were statistically significantly higher. hypophosphatemia in P1A, hypokatemia in 1.HR1 and 2.HR3, hyponatremia in 2.HR2, and hypomagnesaemia in 2.HR3 were statistically significantly higher. Hypokalaemia in PM and hyponatremia in PII were statistically significantly less frequent in patients with ex-relapse. Conclusion. It is known that patients receiving chemotherapy with the diagnosis of acute leukemia may develop various electrolyte disorders and related morbidity and even mortality for many reasons. Although the results of this study vary according to the chemotherapy regimen applied, the plasma concentrations of various serum electrolytes in all treatment protocols revealed significant changes when compared to normal reference values. Keywords. Child Diseases, Hematology, Acute Leukemia Treatment, Electrolyte Disorders