Thiol-disulfide homeostasis in diabetic microvascular complications

Thiol-Disulfide Homeostasis in Diabetic Microvascular Complications Introduction and Aim:Retinopathy, neuropathy and nephropathy are microvascular complications of diabetes mellitus. In this study, the role of thiol / disulfide was investigated in the development of diabetic microvascular complications. Material and Method: A total of 266 (94 male, 172 female) individuals were included in this study. Individuals were divided into five groups; Group 1; who have diabetes without any complications for at least 10 years, group 2; diabetic nephropathy, Group 3; diabetic neuropathy, 4; diabetic retinopathy. The fifth group consisted of 50 healthy individuals as the control group, Thiol, disulfide, feroxidase and ischemic modified albumin levels were measured .in the serum obtained from individuals in addition to routine examinations. Results: Nativ thiol, total thiol and nativ thiol / total thiol were found lower in retinopathy group than theat least 10 years diabetes without any complication group, the neuropathic group and the control group. Disulfide / nativ thiol and disulfide / total thiol levels were found to be higher in the retinopathy group than all other groups, also the level of disulfide was higher than the control group and neuropathy group.Ischemia modified albumin (IMA) levels were found to be higher in the neuropathic and retinopathy groups than all other groups. Feroxidase level was found to be lower in the neuropathy and retinopathy groups than the nephropathy group. Conclusion:In this study, it was found that the disruption of the thiol disulphide homeostasis favor of disulfide may play a role in the formation of diabetic retinopathy. Also, it has been shown that increased IMA and decreased feroxidase levels may play a role in the development of diabetic retinopathy and neuropathy.