Evaluation of subgroup blood incompatibilities in newborn infants with hyperbilirubinemia

Hyperbilirubinemia is one of the most common problems in the neonatal period. There are many reasons in the etiology of newborn hyperbilirubinemia. Blood group incompatibilities are also one of these reasons. Objectives: This study was not a general approach to the etiology of hyperbilirubinemia. This study specifically aimed to investigate the frequency of subgroup nonconformities in the etiology, association with blood group incompatibilities and the treatment which is given for hyperbilirubinemia. Materials and Methods: This study was conducted between 1 January 2016 to 30 June 30 2017 to inform about the possible role of subgroup maladies in 240 newborns who were followed up and treated with the diagnosis of hyperbilirubinemia in the neonatal department of the Dicle University Medical Faculty. We looked total blood count, total bilirubin, direct bilirubin and indirect bilirubin, DC test in jaundiced babies. We also looked at the subgroups of maternal and infant blood groups and (D^4+), (E), (e), (C), (C), (Kell), (C ^ w). Findings: Subgroup inconvenience was detected in 32% of the 240 newborn babies taken to work. 35.4% of cases with subgroup incompatibility were found only subgroup incompatibility, which accounted for 11.6% of all jaundice cases. 34.2% of those with subgroup incompatibility were accompanied by OA-OB incompatibility and 35.4% with Rh incompatibility. It was found that 5% of cases that detected subgroup incompatibility were accompanied by both ABO non-compliance and Rh incompatibility for sub-group inappropriateness. (C) incompatibility as the most frequent nonconformity when fully judged by the cases in which the subgroup impropriety is determined; was found to be 43%'in subgroup nonconformities. Likewise (D^4+) incompatibility was found 35%'in subgroup nonconformities. Furthermore, (E) ncompatibility was found 3%'in subgroup nonconformities. DCT positivity was detected in 38% of subgroup irrelevant cases. DCT positivity was detected in 59.1% of the cases with conjunctival involvement (D^4+)+(C). This constituted 16% of cases in which all subgroup incompatibilities were detected. DCT positivity was 57.14% in cases of Rh incompatibility with subgroup incompatibility. Rh incompatibility and DCT positivity in 66.7% of the (D^4+)+(C) nonconformity association. 40.7% of cases with OA and OB incompatibility with subgroup incompatibility were DCT positives. Blood exchange was applied to 16.5% of cases with subgroup inconvenience. (D^4+)+(C), 40.9% of the nonconformity group had blood exchange and this accounted for 69% of the blood exchange cases. Blood exchange was performed in 46.9% of the cases in which Rh and (D ^ 4 +, C) incompatibility were detected, which accounted for 69.2% of the cases of subgroup obsolescence. Only 50% of the cases with (D^4+)+(C) subgroup incompatibility without accompanying Rh and ABO incompatibility were subjected to blood exchange. IVIG treatment was given in 24.1% of the cases with subgroup inconvenience and 57.8% (D^4+)+(C) of these IVIG cases were inconvenient. (Rh)+(D^4+)+(C) incompatibility was found to account for 60% of IVIG treatments, accounting for 47% of all IVIG cases. It was found that 11.1% of cases with OA-OB incompatibility were given IVIG. It was found that 17.85% of cases with subgroup incompatibility that did not accompany Rh and ABO incompatibility were given IVIG treatment. Conclusion: As a result of these findings, we think that sub-group inconveniences which are often overlooked and can not be looked at due to cost, should be investigated. We hope that this study will be examined by friends and that subgroup maladjustment is not overlooked in patients admitted due to hyperbilirubinemia. Keywords: Subgroup incompatibility, neonatal jaundice, hyperbilirubinemia