The relationship between nesfatin-1, vitamin D and oxidative stress in women with polycystic ovarian syndrome

This Study on the roles of total oxidant status (TOS), malondialdehyde (MDA), nesfatin-1, and vitamin D in women with polycystic ovarian syndrome involved 130 participants (PCOS). 80 women with a body mass index (BMI) of 27.54±1.74 kg/m2 were identified as having PCOS, while 50 healthy women with a BMI of 25±48 2.81 kg/m2 served as controls. The results indicated significant increase in the levels of TOS and MDA with a decrease in the levels of vitamin D and nesfatin-1 in PCOS women compared to control. Moreover, the blood glucose level was observed to be higher in PCOS compared to control. Testosterone and Luteinizing Hormone were increased also in PCOS women. On the other hand, Follicle Stimulating Hormone level was non- significantly different between PCOS women and control. Also, PCOS women have shown negative correlation between nesfatin-1 and BMI, and positive correlation between TOS and MDA.