The Effect of alphatocopherol and ascorbic acid on vasospastic vascular wall in rats

SUMMARY The effects of alphatocopherol and ascorbic acid on vasospastic vascular wall in rats. Antioxidant materials have an important role in therapy of cerebral vasospasm. Experimental studies concerning subarachnoid hemorrhage suggest the primary role of free radicals and subsequently lipid peroxidation in the pathogenesis of vasospasm. The purpose of this study was to invastigate the effects of vitamin C and E on vasospasm in Spraque - Dawley rats basilary artery with experimental induced subarachonid hemorrhage.Vitamin C and E were used intra cisternally to inhibit the effects of free radicals and lipid peroxidation on basillary arteries in rats with subarachnoid hemorrhage. Vasospasm was evaluated by conventional histochemical stain techniques with light microscophy. There were significant differences statistically on diamaters, wall thickness, endothelial thicknes of basillar arteries between the therapy and control groups. Morphological examination of basilar artery by light microschopy showed luminal narrowing and few degenerative or proliferative changes of vessel wall in animal with subarachnoid hemorrhage. These results suggested that cerebral vasospasm is caused by smooth muscle contraction and degenerative and proliferative vasculopaty. These 3 processes may be reversible by the effects of vitamin C and E on rat basillar arteries. As a result, we thought that intra cisternal administration of vitamin C and E is effectual in vasospasm with subaracnoid hemorrhage in rats. 40