İntrahepatic cholestasis of pregnancy: Evaluation of fetal and maternal outcomes of 48 cases

Objective: To evaluate fetal-maternal outcomes of the pregnancies complicated by intrahepatic cholestasis and to discuss the pregnancy management in our clinic. Material and methods: In this study, Dicle University Obstetrics and Gynecology, Department of Obstetrics clinic in January 2011 -December 2015 between the applicant and pregnancy induced intrahepatic cholestasis (GBİHK) were evaluated in 48 patients diagnosed. Data were collected on admission and patients by providing hospital archive files. Results: The mean age was 27.6 ± 6.5 diagnosis of intrahepatic cholestasis of pregnancy-induced patients. Three patients had multiple pregnancies. The average gestational age at delivery of the patients was 36.1 ± 3.1. 48% of patients (n=23) gave birth before the thirty seventh week of pregnancy. 5 min Apgar was 8:19 ± 1.73 average. Cesarean birth rate with 56.25% (n=27), respectively. Acceptance rate was 10.6% in the newborn intensive care unit. 76.5% of newborn infants (n=39) were male and 23.5% 'i (n=12) were monitored girl. The rate of passage of meconium in the amniotic fluid of 8.3% (n=4), respectively. Perinatal mortality rate was 3.92%. Maternal mortality was observed. Conclusion: İntrahepatic cholestasis of pregnancy depends on the diagnosis made by clinical signs and laboratory results. The differential diagnosis of the disease must be done carefully, the differential diagnosis should be considered carefully. Antenatal maternal and fetal follow-up should be done carefully, treatment and delivery process should be planned according to the patient. Due to the high risk of premature birth neonatal intensive care needs to be taken into consideration. Key words: Pregnancy, intrahepatic cholestasis, fetal outcomes