Retrospective evaluation of patients followed up with the diagnosis of immune thrombocytopenic purpura, eser dogan, MD., dissertation, Van,

Aim. In this study, it was aimed to examine the patients diagnosed with ITP retrospectively and to determine the clinical features of the patients at the time of admission and the effectiveness of the treatment selection. Method. The study was carried out at the Van Dursun Odabaşı Medical Center Hospital Pediatric Hematology Outpatient Clinic between January 1, 2013 and September 31, 2019, by retrospectively examining the files of 503 patients diagnosed with ITP. Sociodemographic characteristics, diagnosis and treatment characteristics of the patients were recorded. The data were analyzed with appropriate statistical methods in SPSS 21.0 package program, and p <0.05 was considered significant. Results. There were 503 children diagnosed with ITP in the Pediatric Hematology Outpatient Clinic. 52.3% (n = 263) of the cases were male and 47.7% were female (n = 240). 29.8% (n = 148) had upper respiratory tract infection, 7.6% (n = 38) acute gastroenteritis, and 3.2% (n = 16) vaccination history. In the physical examinations at the time of diagnosis, 54.9% (n = 273) ecchymosis, 21.7% (n = 108) nosebleeds, and 20.3% (n = 101) petechia were detected. 69.6% (n = 346) of the cases were in remission within the first three months, 2.8% (n = 14) exceeded three months but within one year, 27.6% (n = 137) In a one-year period, it became chronic without going into remission. During follow-up, 65% (n = 89) of patients with chronic ITP were in remission. 88.7% (n = 446) of all cases in our study went into remission. 40.2% (n = 200) IVIG, 9.1% (n = 45) IVIG + pulse steroid, 7.2% (n = 36) pulse steroid, 2.4% (n = 12) IVIG + low dose steroid was applied, 34.6% (n = 172) of treatment is followed. The rate of patients with chronic ITP is low dose steroid to 6.6% (n = 33), IVIG + low dose steroid to 2.6% (n = 13), pulse to 1.8% (n = 9) steroid, 1.8% (n = 9) IVIG + low dose steroid + Eltrombopag, 1.4% (n = 7) IVIG, 6.2% (n = 31) no treatment. The study found that patients with chronic ITP sex had less remission than men with chronic ITP (p <0.05). They were found in remission (p = 0.024). They were found to be in remission (p = 0.027). It was found that patients with low MPV value, platelet count and sedimentation value were significantly higher in remission (p <0.05). To examine the advantage that you can use statistically in pulse steroid, low dose steroid, and IVIG options with a similar response (p> 0.05). In the selection of treatment in patients with chronic ITP, anti-D treatment received statistically less remission and rechargeable treatments pulse steroid (p = 0.008), low dose steroid (p = 0.021), eltrombopag (p = 0.001), IVIG(p < 0.001) and splenectomy (p = 0.007) were taken in response to treatment. Conclusion. Of the cases diagnosed with ITP, men, younger, diagnosed with epistaxis at the time of application, with a URI story. At the time of diagnosis, it is determined that the frequency of remission is higher in patients with high platelet count and sedimentation value and lower MPV value. It is determined that the frequency of remission is higher in patients with chronic ITP who did not receive Anti-D treatment.