The relation between autophagy gene expression profile and clinical and pathological features of non small cell lung cancer

In recent years, many studies have been made regarding the role of the autophagy in carsinogenesis. In these studies, autophagy both initiate the carcinogenesis and providing survival of cancer cells as well as launching their apoptosis, as opposed to this two role as a mechanism to destroy cancer cells in the direction of that evidence to the task. Especially in the treatment manipulation of autophagy may have some future treatment opportunities (inhibition or activation). But we have not yet to clarify these questions so the data are inadequate. Today, many research focuses on this topic. One of the greatest obstacles in treatment of lung cancer is dysregulation of cancer cell death signalization. In this study we evaluate the autophagy genes expression mechanisms in relation with the expressions of genes in different pathological types in different clinical stages of lung cancer, and also patients with other clinical parameters (such as smoking, survival and progression). But due to some technical data on gene expression in yield of negativity did not reach significant information. The sample has been kept of the number of larger and better preserved in a similar study in the future should be done. Similar to other types of cancer, such as lung cancer in future studies to be done especially in the treatment area will provide very important information.