The relationship between microvascular complications in type 2 diabetes with mean platelet volume (MPV), red blood cell distribution width (RDW), neutrophile lymphocyte ratio (NLR)

INTRODUCTION: Diabetes Mellitus (DM) is a complex syndrome caused by lack of insulin secretion and/or insulin resistance and emerges with high blood glucose levels, along with multiorgan involvement and characterized by micro/macro complications. Treatment process and complications of the disease are huge financial and moral problems for society as well as individuals. OBJECTIVE: Our aim in this study is to determine relationship between regulation of blood glucose leves with red cell distribution width (RDW), platelet count, neutrophil / lymphocyte ratio (NLR) and mean platelet volume (MPV), also to find these as useful markes that predict microvascular compliations or not. We think early precautions in colmpications will contribute patients survival and life quality. MATERIALS and METHODS: In this study, MPV, RDW, glycosylated hemoglobin (HbA1c), neutrophil and lymphocyte counts, microvascular complications (neuropathy, retinopathy and nepropathy) of 60 patiens diagnosed as diabetes and 60 healty individuals have been evaluated retrospectively. Patients with diabetes have been evaluated according to their HbA1c leves. RESULTS: In this study, we evaluate relationship between microvascular compliations with RDW, MPV, NLR. There was statistically significant difference between nephropaty with RDW, MPV, and NLR(respectively p: 0.008, p: 0.014 and p: 0.017). There was statistically significant difference between retinopathy with RDW and MPV (respectively p: 0.036 and p: 0.019), no statistically difference with NLR (p: 0.129). Within neuropathy, there was statistically significant difference between neuropathy with RDW and NLR (respectively p: 0.001 and p: 0.045), no relationship with MPV (p: 0.157). CONCLUSION: We evaluated relationship between microvascular complications with RDW, MPV, NLR; that we can simply determine by hemogram from patients admitted to hospital. These parameters are benefical and cost-efective markers that we established. However, it will be beneficial to examine whether RDW, MPV and NLR have a role or not in more clinical trials and with more DM patients while following them.