The investigation of the effect of propolis and caffeic acid phenethyl ester on the system of oxidan/antioxidan in the tongue tissue of rats exposed to total cranial irradiation

In this study, we aimed to investigate the protective effects of propolis and caffeic acid phenethyl ester (CAPE) in preventing harmful effects of free radicals resulting from ionizing radiation. In this study, 54 male Wistar-Albino rats were used. The study groups consisted of 6 subgroups consisting of 3 control, radiotherapy (R), propolis + R and CAPE + R All of the groups except the control groups received a single dose of 5 Gy of radiotherapy on the first day. Biochemical parametres of the tongue were measured by spectrophotomety method in order to determine whether propolis and CAPE have protective effects or not. The total SH values in the propolis + R group were found to be statistically significantly higher than in all other groups. In group R, PON values were found to be significantly lower than in all other groups. The TAS values in the propolis + R group were statistically significantly higher when compared to all other groups except the normal control group. As a result of the analyses in terms of oxidant parametres, it was determined that LOOH, TOS, XO and OSI values in group R were significantly higher than the other groups. In addition, the OSI values in the control group of CAPE + R were found to be statistically significantly higher when compared to all other groups except the control group of propolis + R. These results suggest that propolis and CAPE have antioxidant effects against the damage caused by ionized radiation and the use of these substances against the harmful effects of ionized radiation will provide beneficial results. Key words: Radiation, Caffeic acid phenethyl ester, Propolis, Total antioxidan status, Total oxidan status