Investigation of mitochondrial dysfunction in childhood migraine patients

Introduction: The aim of our study was to determine the role of mitochondrial dysfunction in the etiopathogenesis of childhood migraine patients and to determine the role of CGRP (calcitonin gene-related peptide), FGF-21 (fibroblast growth factor-21), GDF-15 (growth/differentiation factor 15) and NOS (nitric oxide). synthase) levels in the diagnosis and treatment of migraine. Materials and Methods: A group of 32 patients (25 girls, 7 boys) and 26 healthy Control Groups (17 girls, 9 boys) who were followed up with the diagnosis of migraine who applied to Düzce University Research and Practice Hospital Pediatric Neurology Outpatient Clinic were included in the study. Serum CGRP, FGF-21, GDF-15 and NOS levels were measured in the ictal and interictal period in the Patient Group and at the time of admission in the healthy control group. Results: In our study, a statistically significant difference was found for serum CGRP and FGF-21 levels in the ictal and interictal periods in the patient group (p<0.001 and p=0.001, respectively). In our study, in the comparison between the ictal period of the patient group and the control group, serum GDF-15 and CGRP levels were found to be statistically significantly higher in the patient group compared to the control group (p<0.001 and p=0.001, respectively). Between the interictal period of the patient group and the control group, serum GDF-15 and CGRP levels were also statistically significantly higher in the patient group. (p<0.001 and p<0.001, respectively). Conclusion: The result of our study supports the existence of mitochondrial dysfunction in the pathogenesis of migraine in childhood.In addition, measurement of serum CGRP and GDF-15 in migraine patients can be used as a biomarker in the diagnosis and may contribute to new treatments to be developed in the prophylaxis of migraine. The result of our study supports the existence of mitochondrial dysfunction in the pathogenesis of migraine in childhood. In addition, measurement of serum CGRP and GDF-15 in migraine patients can be used as a biomarker in the diagnosis and may contribute to new treatments to be developed in the prophylaxis of migraine.