Akut iskemik inmede serum miyeloperoksidaz seviyeleri ve prognoz üzerine etkisi

Ischemic stroke is a pathological condition with acute onset that is caused by the infarction of brain tissue. The most commonly mentioned etiological factor among those is the role of inflammation in stroke. There is a growing number of evidence suggesting the role of inflammatory process in the etiology of aterogenesis and acute cerebral ischemia. Oxidative stress and inflammation also contribute into pathogenesis of atherosclerosis. Myeloperoxidase enzyme (MPO) is a lyzozomal enzyme secreted from leukocyte as a response to oxidative stress. MPO, as an enzyme present in abundant amount in leucocytes and creating reactive oxidant metabolites, plays an active role in atherosclerotic reactions and presents catalytic activity.The aim of this study was to evaluate the effect of myeloperoxidase levels on the prognosis of acute ischemic stroke patients. The sample of the study consisted of 55 inpatients who received a diagnosis of acute ischemic cerebrovascular disease and 40 healthy age and sex matched individual as a control group. Plasma MPO levels of the patients have been measured in the first 24 hours after initial stroke and at the 5th day after stroke. MPO levels in the patients were significantly higher than the control group (p<0.0001). Increased levels of MPO was an important indicator for mortality as patients who survived six months had significantly lower levels of MPO than the ones who deceased (p<0.0001).The results of this study have showed that plasma MPO levels significantly increase in acute ischemic stroke patients and had a significant correlation with prognosis. Larger studies are warranted for better understanding of the role of MPO levels in inflammatory response that appears after aterogenesis and post stroke periods.