Relationship between corrected QT and QT dispersion with serum iron studies in hemodialysis and periton dialysis patients

Objective: In advanced renal disease, the cause of death is atypical and classicalmyocard infarction is not relatively so common. Sudden death and progressive cardiacfailure is more often. Prolonged QT interval in a conventional ECG shows a relation toarytmic situations in some cardiac illnesses. It is reported that increased QT dispersionis a risk factor of serious ventricular arythmies and it shows local pathologicalheterogen fibrosis of cardiac tissues. In chronic renal failure, after blood transfusion andiron replacement for restoring anemia, there is an iron storage in parencymal tissues.The stored iron in heart causes myocardial fibrosis. We designed this research to studythat the relations between iron parameters and QTd and QTc dispersions indicating localheterogenicity related with myocard repolarization.Materials and Method: A total of 60 patients, 35 female and 25 male, includedin this study. They were under treatment of hemodialysis and periton dialysis, receivingerythropoetin and iron replacement regularly, have no other systemic diseases ascardiac failure, diabetes mellitus, ischemic heart disease, a current infection, any blockin ECG, or any arythmies such as atrial fibrillation, bradicardy or tashicardy, anymedicine usage affected QT interval or electrolyte problems. Thirty of them were underperiton dialysis and 30 of them were under hemodialysis. In first group receivinghemodylasis, by first day after routine hemodialysis process, we took their bloodsamples and ECG records. A group of 30 healthy people having same demographicfeatures with the study group was constructed as the control group. We applyied sameexaminations with them and took their ECG records too. By using Bazet formule, weestimated their QT intervals. The difference between the longest QTc and the shortestQTc was estimated as QTc dispersion.Results: The hematocrit and hemoglobin values of hemodialysis and peritondialysis groups were signifiantly lower than values of control groups. We found thatQT intervals of hemodialysis and periton dialysis groups were longer than controlgroup?s value. Although, QTc and QTd was not related to age, gender and dialysistypes, QTc was related to age of dialysis. Our study showed there were significantrelations between QTc and hemoglobin, hematocrit, HDL and ferritin. Also incorrelation tables, there were positive correlations of QTc to dialysis age, parathyroidhormone, sedimentation and ferritin, and negative correlations to hemoglobin,hematocrit and HDL. QTd has just a relation to parathyroid hormone.Conclusions: We showed that dialysis patients have longer QTc and QTdispersions according to indiviudals having normal renal functions. There was norelation between iron and transferin saturations and QTc and QT dispersions. Theresults of currently study suggest that anemia, atherosclerosis and calcium phosphormetabolism are more powerful parameters on QT interval prolongation.