The prognostic importance of the systemic inflammatory response index and the systemic response index in COVID-19 patients

COVİD-19 can cause a wide range of effects on patients, from asymptomatic cases to mortality. Many factors can affect the prognosis of the disease. Our study aims to evaluate the predictive power of the Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) in determining prognosis and mortality in patients. Patients who tested positive for COVİD-19 by polymerase chain reaction and presented to the emergency department of Mersin University Hospital between September 1, 2020, and August 31, 2021, were included in the study. The data of the patients were retrospectively analyzed. A total of 446 patients were included in our study. The rate of patients with severe disease was 55.6%, and the mortality rate was 30.5%. It was found that mortality increased with age (p<0.001). SII and SIRI levels were found to be higher in patients who died or had severe disease (p values were p<0.001). Regarding the SIRI parameter, it was found that patients with values above 1.648 could experience severe COVİD-19 disease (p<0.0001, AUC=0.689), and patients with SIRI levels above 2.057 could experience mortality (p<0.0001, AUC=0.640). When evaluated in terms of the SII parameter, it was found that patients with values above 867.834 could have severe disease (p<0.0001, AUC=0.744), and patients with SII levels above 1370.353 could experience mortality (p<0.0001, AUC=0.682). In COVİD-19-positive cases, it was found that SII and SIRI parameters could predict the severity and mortality of the disease. Further comprehensive studies are needed to determine the future role of these indices.