Synthesis and characterization of functionalized chiral nanoparticals with R(+)-?-methylbenzylamine

(R)-mandelic acid as an anti-bacterial treatment of urinary tract infections, the treatment of skin disorders, skin care products, adult acne is used to resolve the problems of (S)-mandelic acid is used in many animal health and animal care medicine. Therefore, it is important resolution of racemic mandelic acid. In this study, for the chiral resolution of racemic mandelic acid preparation and characterization of magnetic nanoparticles is intended.For this purpose, magnetite (Fe3O4) nanoparticles were synthesized by co-precipitating Fe+2 and Fe+3 in an ammonia solution. Appropriate functional groups in the surface of magnetic nanoparticles using the sol-gel method tetraethylorthosilicate for attaching coated with silica. 3-Glycydoxypropyldimethoxymethylsilane the R(+)?-methylbenzylamine be enabled and the resulting product is attached to the surface of the silica-coated magnetic nanoparticles. X-Ray Diffraction (XRD), Zeta-Potential and Mobility Measurement, Fourier Transform Infrared Spectroscopy (FT-IR), Transmission Electron Micrograph (TEM), Scanning Electron Microscopy (SEM) methods were used to characterize the surface modified magnetic nanoparticles. XRD (Scherer?s equation) and TEM results indicate that the primary particle size of magnetite was around 11 nm. R(+)?-methylbenzylamine anchored to the surface of the silica-coated magnetic nanoparticles is shown by FT-IR spectrophotometer. The particle size distribution of Fe3O4@SiO2 core?shell magnetic nanoparticles was shown by Zeta-Potential and Mobility Measurement and Scanning Electron Microscopy (SEM) methods. The average particles agglomeration size of Fe3O4@SiO2 particles was ca.~500 nm.