The relationship of 25 hydroxy vitamin D3 and thyroid antibodies to thyroid benign-malignant neoplasms

BACKGROUND: Thyroid cancers are the most common malignant tumors of the endocrine system. Covering approximately 1% of all malignancies and the annual incidence continues to rise. In Some retrospective and metaanalysis studies; low vitamin D levels may increase the risk of developing some types of cancer (colorectal, breast, prostate, and bladder cancer). In addition, vitamin D insufficiency has been associated with an increased incidence of metastasis and recurrence in advanced colorectal, breast and prostate cancers. The incidence of positive thyroid antibodies is about twice as much as that of the general population in thyroid carcinomas. In addition, preoperative evaluation of thyroid antibodies is suggested in terms of predicting malignancy prospects and papillary thyroid carcinoma severity in thyroid nodules. In our study, it was aimed to investigate the level of vitamin D, thyroid antibodies and benign-malign neoplasms in patients who underwent thyroidectomy for thyroid nodule in our region. METHOD: This study; We constructed 179 patients who applied to the endocrinology clinic of Van Yüzüncü Yıl University Medical Faculty (YYÜ) Hospital and thyroidectomy for thyroid nodule. Acceptance of ethics was taken from the local ethics committee. Criteria for entry into the study for patients were identified as having no previous blood transfusion, no medication and no mineral supplements, no chronic renal insufficiency, and having patology result in patients underwent tyroidectomy. Vitamin D and thyroid antibodies were retrospectively reviewed. RESULTS: A total of 179 patients diagnosed with thyroid nodules were included in the study and were followed up at the Department of Medical Endocrinology of Yüzüncü Yıl University Medical Faculty. D vitamine levels were 15.016±5.3579 ng / ml. The mean age of the patients was 44.97±14.19. In our study, anti thyroglobulin antibodies were detected in 95 patients and anti thyroid peroksidaz antibodies in 58 patients. In our study, there was no significant relationship between thyroid benign-malign neoplasms and vitamin D levels and thyroid antibodies. When the various thyroid pathologies were compared in terms of vitamin D level, there was no significant effect (p: 0056), but the lowest level of vitamin D was detected in the group of folikuler thyroid carsinoma (mean: 9.967 ng / ml). CONCLUSIONS: It is known that low vitamin D levels may increase the risk of certain types of cancer (colorectal, breast, prostate and bladder cancer). In our study, vitamin D deficiency was present in almost all of the thyroid cancer patients. We did not find any association between vitamin D levels and benign-malignant neoplasm. We have seen that folikuler thyroid carsinoma patients have the lowest concentrations of D vitamins, with only a small number of cases. The incidence of positive thyroid antibodies is about twice as much as in the general population in patients with differentiated thyroid cancer. The presence of thyroid antibodies in thyroid nodules is suggested to be a risk factor for suspicious or malignant cytology. In our study, we did not find any relation between thyroid antibodies and benign-malign neoplasm. More comprehensive and prospectively designed studies are needed to better demonstrate the relationship between vitamin D, thyroid antibodies, and thyroid benign-malign neoplasms.