Evaluation the role of interleukin-17 and interleukin 37 in pathogenesis of type-2 diabetes

Diabetes is a serious non-communicable disease of two types of different pathophysiology. Since they cause a great impact on health, thus no effort is spared in investigating the risk factors of the disease. In this thesis was aimed to determine the correlations between diabetes and interleukins (17 and 37). 140 persons from Al-Jamhoury general hospital in Kirkuk in Iraq were randomly selected, were 70 of them had the disease and another 70 were free of the disease, 35 of each group were females and 35 of them were males, after ethical approval. Each blood samples were investigated for vitamin D level, blood urea level, serum creatinine, lipid profile test (cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein) in addition to patients' glycemic status (fasting blood glucose and hemoglobin A1C) and interleukins 17 and 37. Results showed that interleukin 17 and 37 were found to be significantly higher in the patients' group and were correlated with fasting blood sugar and hemoglobin A1C with a negative correlation with both age and body mass index. It also determined the glycemic status to be negatively correlated with age, weight, vitamin D, blood urea, and dyslipidemia.