CYP1A1 gene in prostate cancer of m1(T>C) and m2 (A>G) polymophism investigation of the possible role

Prostate cancer develops when abnormal cells in the prostate gland grow uncontrollably and form malignant tumors. Studies examining the relationship between prostate cancer and polymorphisms of the CYP450 system are getting more and more attention. Studies conducted to date have found that polymorphisms in the CYP016 enzyme family and subgroups are significantly associated with cancer types such as breast cancer, lung cancer, oral cancer and colorectal cancer. In the light of this information, the possible relationship of m1(T>C; rs4646903) and m2 (A>G; rs1048943) polymorphisms associated with the CYP1A1 gene, one of the CYP-450 enzymes, with prostate cancer and BPH was investigated. (Benign Prostatic Hyperplasia) patients were used as the control group and it was aimed to determine the allele frequency of CYP1A1 polymorphisms in our region with the data of the healthy control group. The study included 60 patients diagnosed with prostate cancer, 40 patients diagnosed with Benign Prostatic Hyperplasia, and 30 healthy individuals who applied to the Urology outpatient clinic of MEU Hospital, who met the inclusion criteria. 2 ml blood samples were taken from the patient and control groups into hemogram tubes with EDTA and DNA isolation was performed using a DNA isolation kit (Roche Diagnostics, GmbHMannheim Germany). LightCycler 480, GmbHMannheim, Germany) was performed. Statistical analyzes Statistica v.13.3.0 and MedCalc v.11.5.0. It was done with a package program and the results were considered significant if p<0.05. When the study data are examined; CYP1A1 (rs1048943) polymorphism AA, GG and AG genotypes (p=0.81) and CYP1A1 (rs4646903) polymorphism TT and TC genotypes (p=0.007) were significant between the patient group and the control group and compared with the control group subgroups. no relationship was detected. Since there are not enough studies on this subject, we think that the data we obtained will contribute to the literature.