The relationship between basal and follow-up uric acid and complete blood count parameters and patients death and survival that are followed at oncology outpatient and inpatient clinic

Object: Uric acid (UA) has been accused of being a risk factor in many diseases and the increase of its level has been evaluated as a risk factor for gout, hypertension and cardiovascular diseases. Besides this, the high level of UA in people having Parkinson's disease, Multiple Sclerosis and Alzeheimer has been shown as being protective. However, there have been contradictory results especially in the studies made in terms of causing or preventing malign diseases. Method: It has been researched whether there is a relation between "the UA results during the diagnosis and/or in one month at the latest of the patients who applied to the polyclinic and/or service of Ege University Medical Faculty Hospital, Department of Oncology from January 2014 till August 2015" and "death and survival" and whether it has value in terms of determination of prognosis. Findings: 428 (%43) patient's UA values of 997 patients have been reached. Average UA values for all of the patients was 4,79 (± 1,82) mg/dl, for survivors (260 people, %65) 4,57 (± 1,53), for death patients (140 people, %35) 5,20 (± 2,22) (p=0,0006). UA referance rage was taken as 3,5-7,2 mg/dl for men, as 2,6-6 mg/dl for women. It was realized that UA levels of 336 patients were normal, of 62 were high and of 30 were low. When we categorized UA levels into low, normal and high, average survival period of 148 (428) patients was 18,201 ± 1,426 months (95% CI 15,407-20,995) in the low group, 70,962 ± 10,244 months (%95 CI 50,884-91,041) in the normal group and 20,571 ± 2,779 months (95% CI 15,125-26,017) in the high group. When we compared all 3 groups with each other, the lifetime between low and normal groups was found significant (p:=0,030), the lifetime between high and normal groups was also found significant (p=<0,001). When low group was compared to high group, it was determined that there was no significance with regard to survival (p=0,304). Result: It seems that UA has both pro-oxidant and anti-oxidant features. It behaves as anti-oxidant in normal levels or as pro-oxidant in high levels. KEY WORDS: Uric Acid, Cancer, Mortality