Biochemical and molecular markers of workers working at the electricity power station in Iraq

The aim of this study to Investigate the relationship between biochemical, haematological markers and Molecular markers of heavy metals effects and occupational lead exposure, and The goal of this study was to look at the levels of heavy metals (pb,Cd, Cu, Fe) in workers who had been exposed to pollution in electricity production station, as well as the levels of Biochemical makers (Cat,SOD, GSH, MDA, CRE, Bun, T.P.,AlP.,GOT, GPT), and the detection CYP3A53 gene polymorphisms associated with enzymatic activity. The research population was split into two subgroups: 20 people (exposed Workers) 10 person (Control). The Results indicated that the most of concentrations of measured metals were fluctuated during study, the highest concentration of Cu (41.4 ppm) found in exposed workers, for biochemical markers which appeared the increasing of all biochemical markers especially Bun and GPT (30.13 mg/dl, 26.10 IU/l) respectively. All antioxidants showed the elevation in concentration for exposed workers, Regarding Molecular markers, the results indicate the polymorphism in most samples except 1, 4, 6, 7, 18, 23), the single-nucleotide polymorphism (SNP) of CYP3A53 associated with enzymatic activity for heavy metals metabolism we concluded that exposed workers effected by the pollution by heavy metals in working station.